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Structural alterations of the brain evident on MRI 7 years before amyloid plaques in AD patients

Radiology Business · 20 August 2026

According to Radiology Business, new findings add to the growing body of evidence pointing to earlier structural alterations as clues that could signal the future development of Alzheimer's disease. These brain changes are evident on MRI seven years before amyloid plaques appear.

The research highlights these structural alterations as potential early indicators of the condition. This occurs even before a high amyloid burden is evident in patients.

Structural alterations of the brain evident on MRI 7 years before amyloid plaques in AD patients